Its health effects include hepatotoxicity and male reproductoxicity, possibly linked with mitochondrial dna mtdna alterations. Hhhhh dmf is prepared by combining methyl formate and dimethylamine or by reaction of dimethylamine with carbon monoxide. It is a precursor for numerous reactions such as formylation. Identification product name n,n dimethylformamide d7 casno 4472417 synonyms no information available recommended use laboratory chemicals. This organic solvent is used in acrylic fiber spinning, chemical manufacturing, and pharmaceutical production. Safety data sheet n,ndimethylformamide bdh 1117 vwr. Acetylene, dissolved in dmf 100 74862 ingredient name % cas number there are no additional ingredients present which, within the current knowledge of the supplier and in the. N,ndimethylformamide is considered to be a potent liver toxin. Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. Substancepreparation and company identification material. Product identification name dimethylformamide synonyms n,ndimethylformamide, nformyldimethylamine, dmf. Vithane resins in dimethylformamide dmf are a family of polyurethane elastomers manufactured and marketed by rohm and haas company, a wholly owned subsidiary of the dow chemical company, and its affiliated companies. Material safety data sheet methanol southern chemical. Chemical information document 2 sourcing compliant formulations from your chemical suppliers communicate with the responsible person for chemical management at upstream.
It is a volatile organic compound and a member of formamides. Page 1 of 10 material safety data sheet methanol product name methanol ch 3oh synonyms alcohol, methyl hydroxide, methyl hydrate, wood alcohol, wood spirit product use. Dec 01, 2019 dmf is used in the production of acrylic fibers and plastics. It can harm the eyes, skin, lungs, liver, and heart. Use water spray, alcoholresistant foam, dry chemical or carbon dioxide. In case of skin contact wash off with soap and plenty of water. As for most amidesthe spectroscopic evidence indicates partial double bond character for the cn and co bonds. Cdc niosh publications and products preventing adverse. Dmf is used in the production of acrylic fibers and plastics. Workers may be harmed from exposure to dimethylformamide. Jul 24, 2019 hhhhh dmf is prepared by combining methyl formate and dimethylamine or by reaction of dimethylamine with carbon monoxide. Page 1 of 9 msds dimethylformamide material safety data sheet msds dimethylformamide 1. This chemical is one of the components of the antibody array assay kit.
According to the information received during the public consultation from industry stakeholders of the chemical, pharmaceutical and textiles sectors 6 rcom, 2012, as well as from the gas sector association rcom, 2014, research for alternative solvents andor. Safety data sheet northwest missouri state university. Material safety data sheet n,n dimethylformamide msds section 1. Msds dimethylformamide page 1 of 9 material safety data sheet. The user must determine suitability of this information for his application. For other components in the kit, please refer to individual material safety data sheet. Uses advised against food, drug, pesticide or biocidal product use. A new method for the preparation of secondary and tertiary p alkylaminobenzaldehyde. Panjiva uses over 30 international data sources to help you find qualified vendors of chemical dmf. Identification product name n,ndimethylformamided7 casno 4472417 synonyms no. The cas number is the substance numerical identifier assigned by the chemical abstracts service, a division of the american chemical society, to substances registered in the cas registry database. N,n dimethylformamide included in the candidate list of substances of very high concern svhc. Dmf is miscible with water in all proportions and is a powerful solvent for a variety of organic, inorganic, and resin products.
Dmf is one of a class of solvents designated as polar aprotics. Dimethylformamide is an organic compound with the formula ch 3 2 ncoh. Toxicity data skin rabbit 4,720 mgkg ld50 oral rat 2,800 mgkg ld50 6 hr. Dimethylformamide please ensure that this sds is given to, and explained to people using this product. Its appearance should serve as a warning that control of exposure to dmf has. Thf material safety data sheet msds tetrahydrofuran 1. N, ndimethylformamide dmf is a clear liquid that has been widely used in industries as a solvent, an additive, or an intermediate because of its extensive miscibility with water and most common organic solvents. Sodium hydroxide safety data sheet according to federal register vol. N, n dimethylformamide dmf is a solvent with a low evaporation rate, useful for preparing solutions with a variety of hydrophobic organic compounds used in molecular biology applications. Nmr solvents deuterated solvents for nmr nmr solvents nmr reference standards nmr tubes. Us epa guidelines for the classification determination are listed in 40 cfr.
Commonly abbreviated as dmf although this initialism is sometimes used for dimethylfuran, or dimethyl. N,n dimethylformamide is a member of the class of formamides that is formamide in which the amino hydrogens are replaced by methyl groups. Application n,n dimethylformamide was used to solubilize mtt crystals in cell viability assays. Use carbon dioxide, dry chemical or foam for extinction. If inhaled if breathed in, move person into fresh air. Acetylene, dissolved in dmf 100 74862 ingredient name % cas number there are no additional ingredients present which, within the current knowledge of the supplier and in the concentrations applicable, are classified as hazardous to health or the environment and hence require reporting in this section. Dimethylformamide dmf is a clear, colorless, watersoluble liquid that is used primarily as a. Safety data sheet creation date 12jan2015 revision date 19jan2018 revision number 4 1. Dimethylformamide dmf is a colorless, watersoluble liquid with a faint ammonialike odor.
Hconch32 material safety data sheet n,ndimethylformamide msds. Dimethylformamide solvent for peptide coupling, used as a wash after each deprotection and coupling step in tboc, used as a solvent in fmoc, solvent with low evaporation rate, catalyst in synthesis of acid halides. View or download the n,ndimethylformamide msds material safety data sheet or sds for 103034 from merck. Aug 15, 2019 dimetyylformamide wikipedia, the free encyclopedia. Immediately flush eyes with plenty of water for at least 15 minutes, lifting upper and lower eyelids occasionally. The information provided in this safety data sheet is correct to the best of our knowledge, information and belief at the date of its publication. N,ndimethylformamide included in the candidate list of substances of very. Its appearance should serve as a warning that control of exposure to dmf has been inadequate. The solvent properties of dmf are particularly attractive because of the high dielectric constant, the aprotic nature of the solvent, its wide liquid range and low volatility. General description n,ndimethylformamide dmf is a polar organic solvent with a wide range of industrial applications.
Elastomers are resilient polymers that can bend or stretch and then return to their original shape. If there is significant potential for skin contact, monitoring should be done to measure the level of dmf metabolites in urine specimans at the end of the shift. None information in this msds is from available published sources and is believed to be accurate. Dmf is a polar hydrophilic aprotic solvent with a high boiling point. The solvent properties of dmf are particularly attractive because of the high dielectric constant, the. Warn or evacuate occupants in surrou nding and downwind areas if required due to toxicity or. Chemical information document 2 sourcing compliant formulations from your chemical suppliers communicate with the responsible person for chemical management at upstream suppliers to ensure formulations meet brand requirements. No warranty, express or implied, is made and labchem inc. Chemical dmf manufacturers suppliers of chemical dmf. Chemical identity type exposure limit values source dimethylformamide twa 10 ppm us. It acts as a catalyst in the synthesis of acyl chlorides. As for most amidesthe spectroscopic evidence indicates partial.
Inventory of existing chemical substances produced or imported in china. Acgih threshold limit values 2011 rel 10 ppm 30 mgm3 us. Osha table z1 limits for air contaminants 29 cfr 1910. Dow expects you to follow the precautions identified in this document unless your use conditions would necessitate other appropriate methods or actions.
Avoid contact with dimethyl sulfoxide dmso solutions containing toxic materials or materials. Check regularly the formulation and sds from your chemical supplier to ensure dmf is not being added. It is a precursor for numerous reactions such as formylation, aminocarbonylation, amination, amidation and cyanation. Because of human variability the onset of the reddening effect is not an acceptable means of selfmonitoring for dmf overexposure.
N, ndimethylformamide dmf is a clear liquid that has been widely used in industries as a solvent, an additive, or an intermediate because of its extensive miscibility with water and most. Dimethyl sulfoxide page 2 of 5 cause liver and kidney damage. N, ndimethylformamide is commonly used as a solvent. Pocket guide to chemical hazards 2010 pel 10 ppm 30 mgm3 us. Material safety data sheet section 1 n,ndimethylformamide 1 chemical product and company identification msds name. Show this safety data sheet to the doctor in attendance. Chemical used in synthesis andor formulation of industrial products. It is used for separating and refining crude from olefin gas. Identification of the substancemixture and of the companyundertaking product name. Dimethylformamide dmf is a clear, colorless, watersoluble liquid that is used primarily as a dipolar aprotic solvent. Canadian association of chemical distributors safety data.
Dmf along with methylene chloride acts as a remover of varnish or lacquers. Dmf is widely used as a solvent, reagent and catalyst. Dimethylformamide dmf chemical economics handbook ceh. To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated. Canadian association of chemical distributors safety data sheet 1. Dimethylformamide dmf is a clear, colorless, hygroscopic liquid with a slight amine odor. This high solubility of inorganic substances also leads to the application of dmf in the production of high voltage capacitors. Commonly abbreviated as dmf although this initialism is sometimes used for dimethylfuran, or dimethyl fumarate, this colourless liquid is miscible with water and the majority of organic liquids. Chemical information document for dimethylformamide dmf.
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